BioImaging Austria - CMI (Correlated Multimodal Imaging Node Austria)

BioImaging Austria - CMI (Correlated Multimodal Imaging Node Austria)

Vienna | Website

Core facility (CF)

Short Description

CMI is the official Austrian Euro-Bioimaging initiative of leading imaging experts in Austria. It was established as a consortium of eight universities and research institutes in and around Vienna to foster correlated multimodal imaging across scales in life sciences. Correlated imaging gathers information about the specimen with two or more complementary modalities that – sequentially combined – create a highly informative, composite view of the sample.

CMI offers a multitude of basic and high-end state-of-the-art imaging technologies from MRI to super-resolution microscopy as stand-alone technologies, numerous multimodal correlated imaging pipelines, and various support services, such as data and image analysis, to researchers and scientists on a national and international level. Imaging techniques at CMI span the entire resolution range of interest for preclinical and biological studies, and provide complementary sample information about structure, function and molecular composition. The more than 35 imaging techniques allow both in- and ex-vivo imaging and molecular analysis. Particularly, CMI is developing and setting up entirely new multimodal workflows at the forefront of correlated imaging, which can involve more than two imaging modalities and explicitly go beyond CLEM (Correlative Light and Electron Microscopy) and hybrid imaging.

Contact Person

Dr. Andreas Walter

Research Services

All available imaging techniques are listed in alphabetical order below - and can be combined in multimodal workflows to address the specific biomedical research question best:

Atomic Force Microscopy (AFM)
Bioluminescence Imaging
Brillouin Spectroscopy
Computed Tomography (CT)
In-vivo μCT
Ex-vivo μCT
Confocal Microscopy
Electron Microscopy (EM)
Cryo Electron Microscopy (Cryo-TEM)
Cryo Electron Tomography (Cryo-ET)
Scanning Electron Microscopy (SEM)
Transmission Electron Microscopy (TEM)
Fluorescence Anisotropy Imaging
Fluorescence Correlation Spectroscopy (FCS)
Fluorescence Lifetime Correlation Imaging (FLCS)
Fluorescence Lifetime Imaging Microscopy (FLIM)
Fluorescence Microscopy
Fluorescence Recovery After Photobleaching (FRAP)
Foerster Resonance Energy Transfer (FRET)
High-Resolution Episcopic Microscopy (HREM)
Light Sheet Fluorescence Microscopy (LSFM)
Magnetic Resonance Imaging (MRI)
Ultra-High Field μMRI (15.2 T)
Intermediate μMRI (9.4 T)
MRI (1 & 1.5 T)
Mass Spectrometry (MS)
Mass Spectrometry Imaging (MSI)
Time-of-Flight Mass Spectrometry (ToF-MS)
Matrix-Assisted Laser Desorption/Ionization (MALDI)
Desorption Electrospray Ionization (DESI)
Optical Coherence Tomography (OCT)
(Quantitative) Positron Emission Tomography (μPET)
Photoacoustic Imaging (PAI)
Photoactivated Localization Microscopy (PALM)
Raman Spectroscopy
Single Molecule Tracking
Single-Photon Emission Computed Tomography (μSPECT)
Stochastic Optical Reconstruction Microscopy (STORM)
3D Structured Illumination Microscopy (3D-SIM)
TissueFAXS (Automated Microscopy-Based Tissue Analysis)
Total Internal Reflection Fluorescence Microscopy (TIRF)
(High-Frequency) Ultrasound (US)
X-Ray Fluorescence Spectrometry (XRF)
Total Reflection XRF

CMI also offers a variety of support facilities to ensure that the experiments have the best outcome. Below is a list of support services in alphabetical order:

Animal Facility
Animal Preparation
Operation Rooms
Body Donor Facility
Dissection & Harvesting
Cell Culture Facilities – Safety Level 1
Cell Culture Facilities – Safety Level 2
Data Analysis
Automated Segmentation & Feature Detection
Big Data Analysis
Data Visualization
Image Analysis & Quantification
Image Registration
Machine Learning
(Multi-Modal) Image Data Fusion & Integration
Numerical Simulations
In-situ Hybridization
Laser Capture Microdissection
Radiotracer Facility
Radionuclides & Radiochemistry
Sample Preparation
Server/Office Space
Deconvolution Software
Definiens XD
MorphoJ/EVAN/Past/TPS-Dig, TPS-Super
Tissue Engineering Facility
Wet Lab Space

Methods & Expertise for Research Infrastructure

CMI has extensive expertise in providing bioimaging solutions for biological or preclinical research questions to scientists and companies on a national & international level. These can comprise single imaging modalities, multimodal imaging workflows or a variety of support facilities, such as image analysis.

Medical University Vienna
Vienna BioCenter Core Facilities (VBCF)
University of Veterinary Medicine Vienna
Technical University Vienna
AIT Austrian Institute of Technology
Ludwig-Boltzmann Institute for Experimental & Clinical Traumatology
University of Applied Sciences Upper Austria