University of Salzburg

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Large equipment

Short Description

Quadrupole-Orbitrap mass spectrometer for the use in proteome- and metabolome analysis, direct injection with syringe pump or HPLC, ESI source, Nano-ESI source, through availability of special protein-mode particularly suitable for intact protein measurements, additionally high-resolution option up to 250,000

Contact Person

Prof. Dr. Christian Huber

Research Services

Highly sensitive detection and identification of biomolecules

Methods & Expertise for Research Infrastructure

The device is used for highly sensitive detection and identification of biomolecules based on the accurate mass or fragmentation spectra. By means of such measurements, for example, expression profiles of proteins or degradation products of drugs can be analyzed.

Allocation to Core Facility


Prof. Dr. Christian Huber
Fachbereich Biowissenschaften
0043 668 8044 5738
Please contact us via science.plus@sbg.ac.at, or contact the responsible person for this section, mentioned in the contact field
Sandoz Biopharmaceuticals, Kundl, within the framework of the Christian Doppler Laboratory for Biosimilar Characterization
Predict-IV – Profiling the toxicity of new drugs; a non animal-based approach integrating toxicodynamics and biokinetics
Wolfgang Dekant, Koordinator
Commission of the European Communities

MARINA: Managing the risks of Nanoparticles
Lang Tran, Koordinator
Commission of the European Communities

Doktoratskolleg Immunity in Cancer and Allery; W 1213
Josef Thalhammer, Koordinator
Fonds zur Förderung der wissenschaftlichen Forschung

Christian Doppler Laboratory for Innovative Tools for the Characterization of Biosimilars
Christian Huber, Laborleiter
Christian Doppler Forschungsgesellschaft
Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress
Wilmes A., Limonciel A., Aschauer L., Moenks K., Bielow C., Leonard M.O., Hamon J., Carpi D., Ruzek S., Handler A., Schmal O., Herrgen K., Bellwon P., Burek C., Truisi G.L., Hewitt P., Di Consiglio E., Testai E., Blaauboer B.J., Guillou C., Huber C.G., Lukas A., Pfaller W., Mueller S.O., Bois F.Y., Dekant W., Jennings P.
Journal of Proteomics
DOI: dx.doi.org/10.1016/j.jprot.2012.11.022

Quantitative HPLC-MS Analysis of Nucleotide Sugars in Plant Cells following Off-Line SPE Sample Preparation
Behmüller R., Forstenlehner I. C., Tenhaken R., Huber C.G.
Analytical and Bioanalytical Chemistry
DOI: 10.1007/s00216-014-7746-3

Rapid and Comprehensive Impurity Profiling of Synthetic Thyroxine by Ultrahigh-Performance Liquid Chromatography−High-Resolution Mass Spectrometry
Neu V., Bielow C., Gostomski I., Wintringer R., Braun R., Reinert K., Schneider P., Stuppner H., Huber C.G.
Analytical Chemistry
DOI: dx.doi.org/10.1021/ac303722j

Nephron Toxicity Profiling via Untargeted Metabolome Analysis Employing a High-Performance Liquid Chromatography-Mass Spectrometry-Based Experimental and Computational Pipeline
Ranninger C., Rurik M., Limonciel A., Ruzek S., Reischl R., Wilmes A., Jennings P., Dekant W., Kohlbacher O., Huber C.G.
Journal of Biological Chemistry

Site-Specific Characterization and Absolute Quantification of Pegfilgrastim Oxidation by Top-Down High-Performance Liquid Chromatography-Mass Spectrometry
Forstenlehner I., Holzmann J., Toll H., Huber C.G.
Analytical Chemistry
DOI: 10.1021/acs.analchem.5b02029

Chitosan functionalisation of gold nanoparticles encourages particle uptake and induces cytotoxicity and pro-inflammatory conditions in phagocytic cells, as well as enhancing particle interactions with serum components. Journal of Nanobiotechnology
Boyles M.S.P., Kristl T., Andosch A., Zimmermann M., Tran N., Casals E., Himly M., Puntes V., Huber C.G., Lütz-Meindl U., Duschl A.
Journal of Proteomics
DOI: 10.1186/s12951-015-0146-9