JKU - Johannes Kepler University Linz
Linz | Website
Short Description
Filming dynamic biological processes in real-time at nanometer resolution
Contact Person
Univ.-Prof. Dr. Peter Hinterdorfer
Research Services
Watching dynamical structural changes in real time at Nanometer resolution, such as the bi-pedal ‘walking mechanism’ of antibodies on bacterial and viral membranes [ref. 1], as well as filming the thermal motion of membrane protein moieties [ref. 2]. The major expected long-term impact is to arrive at a detailed dynamic and functional picture in understanding the binding and transport mechanism of substrates and pharmaceuticals.
Methods & Expertise for Research Infrastructure
watching dynamical structural changes in real time, such as the bi-pedal ‘walking mechanism’ of antibodies on bacterial and viral membranes, as well as filming the thermal motion of membrane protein moieties. The major expected long-term impact is to arrive at a detailed dynamic and functional picture in understanding the binding and transport mechanism of substrates and pharmaceuticals to aid drug design and develop new therapeutic strategies
Preiner, J., P. Hinterdorfer et al., High-speed AFM images of thermal motion provide stiffness map of interfacial membrane protein moieties. Nano letters, 2015.