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For the measurement of size distribution and the aggregation state of proteins static and dynamic light scattering (SLS/DLS) are commonly used.
Nano-DSF allows to specifically probe the integrity of protein fold, to study internal structural dynamics and stability, as well as to identify true folding/unfolding transitions in a broad range of concentrations in various buffers.
Simultaneous analysis of both intrinsic fluorescence (nanoDSF) and light scattering (SLS/DLS) signals allows to clearly distinguish between native, aggregated and/or unfolded protein states.
The given instrument is a Nanotemper Prometheus Panta
Equipment is user operated. No centralized services.
Methods & Expertise for Research Infrastructure
Equipment is user operated, No centralized services.
Allocation to Core Facility
Advanced user training required.