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The SPOC Laboratory allows high-quality rapid prototyping of biochips and lab-on-chip systems for research purposes. Microfluidic technology enables miniaturized and defined processing of samples, thus opening up new opportunities in the life sciences and related industries, in particular because microfluidics technology currently incorporates existing analytical solutions in the areas of toxicology, environmental testing, food safety and cosmetics, as well as in the veterinary field and medical diagnostics.
The SPOC Lab is a rapid prototyping facility recently opened and furbished to design and build practical solutions for bioanalytics and medical diagnostics, as well as for chip manufacturing and on-site testing of prototypes with a particular focus on miniaturization, automation and sensor integration in order to significantly reduce development times for complex solutions for future research partners
(1) Construction and testing of exemplary biochip prototypes
(2) Technology matrix for prototyping in small numbers for academic and industrial R & D
(3) Academic research and development consulting activities for students and industry to provide through (1-3) Establish sustainable research collaborations with biomedical, pharmaceutical and medical device companies.
(a) Lithography: mask plotter (16250 dpi), spin coater, UV exposure, UV NIL
(b) Material Processing: Micro Mill, Laser Cutter, PDMS casting
(c) quality control: white light interferometry, light microscopy, fluorescence microscopy
(d) fluid test stands and application testing
Prof. Dr. Günter Lepperdinger
CAD Design Mastering (photo mask plotting, soft lithopgraphy, dry resist lithography, milling)
Bioanalytical and biological application testing
Methods & Expertise for Research Infrastructure
The SPOC FabLab offers a combination of manufacturing strategies that cover the important requirements: 3D printing / laser cutting for large structures, mask and maskless lithography for PDMS-based microfluidic chips, milling and hot embossing for plastic chip prototypes. In addition, methods for integrating active functions into chips such as valves, electrodes for sensors, optical waveguides and more besides a variety of protocols for adapting the surface properties of channels to specific requirements (hydrophobic / hydrophilic, biocompatible, ...) are offered. Appropriate protocols and workflows are established to a high standard to ensure stringent quality requirements. New matching technologies are constantly being integrated in order to maintain the high quality and timeliness of the offers. Care is taken to choose prototyping strategies that are compatible with later mass production.
The studio also offers design (CAD) services to help in the prototyping of chips. Due to the complicated IP situation in the field no 'own' chip designs are offered. In this way, it remains the responsibility of the partner to choose and use designs appropriately (research versus commercial) and, where appropriate, to license corresponding IP. The production of microfluidic devices is mainly offered for small series, where mass production is not profitable and therefore not possible. First and foremost, partner-side technologies and assays are to be integrated into prototype biochips and setups, and many questions will be so specific that such issues are not offered by large manufacturers in the necessary breadth and depth and may be built only in a university-academic environment and be tested.
Technical University Graz: Thorsten Mayer
University Salzburg, Department of Chemistry and Physics of Materials: John Dunlop
Stratec Consumables GmbH
Dr. Günter Lepperdinger
Land Salzburg in Kooperation mit Stratec Consumables GmbH und Procomcure Biotech GmbH
Dr. Günter Lepperdinger
Land Salzburg in Kooperation mit Stratec Consumables GmbH
Dr Günter Lepperdinger
FFG K-Project no. 843536
Stigler RG, Schimke MM, Bigus S, Steinmüller-Nethl D, Tillmann K, Lepperdinger G.
Nanomedicine. 2019 Feb;16:250-257.
DOI: 10.1016/j.nano.2018.08.015. Epub 2018 Sep 26.
Hard Tissue Augmentation of Aged Bone by Means of a Tin-Free PLLA-PCL Co-Polymer Exhibiting in vivo Anergy and Long-Term Structural Stability.
Schimke MM, Paul S, Tillmann K, Lepperdinger G, Stigler RG.
doi: 10.1159/000494798. Epub 2019 Jan 24.
Long-lived murine osteocytes are embodied by craniofacial skeleton in young and old animals whereas they decrease in number in postcranial skeletons at older ages.
Stigler RG, Becker K, Kloss FR, Gassner R, Lepperdinger G.
Gerodontology. 2018 Dec;35(4):391-397.
doi: 10.1111/ger.12362. Epub 2018 Jul 27.
A. Krueger Intrinsically 32P-labeled diamond nanoparticles for in vivo imaging and quantification of their biodistribution in chicken embryos
P. Happel, T. Waag, M. M. Schimke, S. Schweeberg, A. Muzha, K. Fortak, D. Heesch, L. Klask, M. Pilscheur, F. Hoppe, T. Lenders, J. Meijer, G. Lepperdinger,
Adv. Funct. Mater.2018, 28, 1802873,
Biofunctionalization of scaffold material with nano-scaled diamond particles physisorbed with angiogenic factors enhances vessel growth after implantation.
Schimke MM, Stigler R, Wu X, Waag T, Buschmann P, Kern J, Untergasser G, Rasse M, Steinmüller-Nethl D, Krueger A, Lepperdinger G.
Nanomedicine. 2016 Apr;12(3):823-833.
doi: 10.1016/j.nano.2015.11.004. Epub 2015 Dec 3.
Lab-on-a-chip technologies for stem cell analysis.
Ertl P, Sticker D, Charwat V, Kasper C, Lepperdinger G.
Trends Biotechnol. 2014 May;32(5):245-53.
DOI: 10.1016/j.tibtech.2014.03.004. Epub 2014 Apr 9. Review. PMID: 24726257