Medical University of Graz
Graz | Website
Short Description
Hochfeld 600 MHz NMR-Spektrometer mit Avance Neo Konsole für die Metabolomik und Strukturbiologie von Biomolekülen und biomolekularen Komplexen. Das System besteht aus einem 14,1 Tesla Magent mit 1H/13C/15N TXI, 1H/BB BBI-Sonden und einem temperaturgeregelten SampleJet Probenwechsler für bis zu 500 Proben.
Contact Person
Assoz. Prof. Tobias Madl
Research Services
Bitte nehmen Sie bei Interesse an Research Services Kontakt mit Assoz. Prof. Dr. Tobias Madl auf:
Email: tobias.madl@medunigraz.at
Telefon: 0043-316-385-71972
Methods & Expertise for Research Infrastructure
- Untargeted und targted Metabolomik aus biologischen Proben (Bioflüssigkeiten, Geweben, Medien, etc.)
- Aufklärung der Struktur und Dynamik von Biomolekülen und biomolekularen Komplexen
- Studien von post-translationalen Modifikationen
- Wirkstoffforschung
Die Nutzungsbedingungen werden in einer Nutzervereinbarung festgelegt. Die Nutzervereinbarung ist in Bearbeitung.
Im Rahmen der Kooperation Omics Center Graz (http://omicscentergraz.at/).
Medizinische Universität Innsbruck, Universität Graz, Technische Universität Graz im Rahmen von Forschungsprojekten.
Universität Graz, Technische Universität Graz im Rahmen von BioTechMed-Graz.
Diverse europäische Universitäten im Rahmen von gemeinsamen Projekten, internationale Kooperationen.
Medizinische Universität Innsbruck, Universität Graz, Technische Universität Graz im Rahmen von Forschungsprojekten.
Universität Graz, Technische Universität Graz im Rahmen von BioTechMed-Graz.
Diverse europäische Universitäten im Rahmen von gemeinsamen Projekten, internationale Kooperationen.
1. Günthner R., Hanssen H., Hauser C, Angermann S., Lorenz G., Kemmner S., Matschkal J., Braunisch M.C., Küchle C., Renders L., Moog P., Wassertheurer S., Baumann M., Hammes H.P., Mayer C.C., Haller B., Stryeck S., Madl T., Carbajo-Lozoya J., Heemann U., Kotliar K., Schmaderer C., Impaired Retinal Vessel Dilation Predicts Mortality in End-Stage Renal Disease, Circulation Research (2019) accepted
2. Burgstaller S., Bischof H., Gensch T., Stryeck S., Gottschalk B., Ramadani-Muja J., Eroglu E., Rost R., Waldeck-Weiermaier M., Hay J.C., Madl T., Graier W.F., Malli R., pH-Lemon, a fluorescent protein-based self-calibrated pH reporter for acidic compartments, ACS Sensors (2019) accepted
3. Stryeck S., Gastrager M., Degoricija V., Trbušić M., Potočnjak I., Radulović B., Pregartner G., Berghold A., Madl T., Frank S., Serum Concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are Associated with Increased 3-Month Mortality in Acute Heart Failure Patients, Scientific Reports (2019) accepted
4. Schopf F.H., Huber E.M., Dodt C., Lopez A., Biebl M.M., Rutz D.A., Mühlhofer M., Madl T., Sattler M., Groll M., Buchner J., The essential co-chaperone Cns1 and the recruiter protein Hgh1 link Hsp90 to translation elongation via elongation factor 2, Molecular Cell (2019) accepted
5. Klec C, Madreiter-Sokolowski CT, Stryeck S, Sachdev V, Duta-Mare M, Gottschalk B, Depaoli MR, Rost R, Hay J, Waldeck-Weiermair M, Kratky D, Madl T, Malli R, Graier WF, Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca²⁺ Leak Directed to Mitochondria in Pancreatic Islets and β-Cells, Cellular Physiology and Biochemistry (2019) in press
6. Stadlbauer V., Horvath A., Komarova I., Schmerboeck B., Feldbacher N., Wurm S., Klymiuk I., Durdevic M., Rainer F., Blesl A., Stryeck S., Madl T., Stiegler P., Leber B., A single alcohol binge impacts on neutrophil function without changes in gut barrier function and gut microbiome composition in healthy volunteers, PLOS One (2019) accepted
7. Huber K., Hofer D.C., Trefely S.. Pelzmann H.J., Madreiter-Sokolowski C., Duta-Mare M., Schlager S., Trausinger G., Stryeck S., Graier W.F., Kolb D., Magnes C., Snyder W.N., Prokesch A., Kratky D., Madl T., Wellen K.E., Bogner-Strauss J.G., N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (2019) in press
8. Madreiter-Sokolowski C., Waldeck-Weiermair M.,Bourguignon N., Villeneuve N., Gottschalk B., Klec C., Stryeck S., Radulovic S., Parichatikanond W., Frank S., Madl T., Malli R., Graier W., Enhanced inter-compartmental Ca2+ flux modulates mitochondrial metabolism and apoptotic threshold during aging. Redox Biology (2018) in press
9. Koyani C.N., Trummer C., Shrestha N., Scheruebel S., Bourgeois B., Plastira I., Kickmaier S., Sourij H., Rainer P., Madl T., Sattler W., Pelzmann B., Malle E., von Lewinski D., Saxagliptin but not sitagliptin inhibits CaMKII and PKC via DPP9 inhibition in cardiomyocytes. Frontiers in Physiology, section Cardiac Electrophysiology (2018) in press
10. Stryeck S., Horvath A., Leber B., Stadlbauer V., Madl T., NMR spectroscopy enables simultaneous quantification of carbohydrates for diagnosis of intestinal and gastric permeability. Scientific Reports (2018) in press
11. Alkan F.A., Walter K.E., Luengo A., Madreiter-Sokolowski C.T., Stryeck S., Lau A.N., Al-Zoughbi W., Lewis C.A., Thomas C.J., Hoefler G., Graier W.F., Madl T., Vander Heiden M.G., Bogner-Strauss J.G., Cytosolic aspartate availability determines cell survival when glutamine is limiting, Cell Metabolism (2018) in press
12. Bourgeois B., Madl T., Regulation of cellular senescence via the FOXO4-p53 axis, FEBS Letters 592 (2018) 2083-2097
13. Lorenz G., Mayer C.C., Bachmann Q., Stryeck S., Braunisch M.C., Haller B., Carbajo-Lozoya J., Schmidt A., Witthauer S., Abuzahu J., Kemmner S., Angermann S., Koneru N., Wassertheurer S., Bieber R., Heemann U., Madl T., Pasch A., Schmaderer C., Acetate Free – Citrate-Acidified - Bicarbonate Dialysis Improves Serum Calcification Propensity – a Preliminary Study, Nephrology Dialysis Transplantation (2018) in press
14. Pollheimer M.J., Racedo S., Mikels-Vigdal A., Marshall D., Bowlus C., Lackner C., Madl T., Karlsen T.H., Hov J.R., Lyman S.K., Adamkewicz J., Smith V., Moreau E., Zollner G., Eide T.J., Stojakovic T., Scharnagl H., Gruber H.J., Stauber R.E., Trauner M.E., Fickert P., Senescence, Hypoxia, and Toxic Bile Promote LOXL2 Expression and E-cadherin Repression Reducing Barrier Function in Cholangiocytes, Journal of Hepatology 69 (2018) 368-377
15. Rutz D.A., Luo Q., Freiburger L., Madl T., Kaila V.R.I., Sattler M., Buchner J., A switch point in the molecular chaperone Hsp90 responding to client interaction, Nature Communications 9 (2018) 1472
16. Cristóvão J.S., Morris V.K., Cardoso I., Leal S.S., Martínez J., Botelho H.M., Göbl C., David R., Kierdorf K., Alemi M., Madl T., Fritz G., Reif B., Gomes C.M., The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation, Science Advances 4 (2018) eaaq1702
17. Hofweber M., Hutten S., Bourgeois B., Spreitzer E., Niedner-Boblenz A., Schifferer M., Ruepp M.D., Simons M., Niessing D., Madl T., Dormann D., Phase separation of FUS is suppressed by its nuclear import receptor and arginine methylation, Cell 173 (2018) 706-719
18. Bischof H., Rehberg M., Stryeck S., Artinger K., Eroglu E., Waldeck-Weiermair M., Gottschalk B., Rost R., Deak A.T., Niedrist T., Vujic N., Lindermuth H., Prassl R., Pelzmann B., Groschner K., Kratky D., Eller K., Rosenkranz A.R., Madl T., Plesnila N., Graier W.F., Malli R., Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo, Nature Communications 8 (2017) 1422
19. Öster C., Kosol S., Hartlmüller C., Lamley J.M., Iuga D., Oss A., Org M.L., Vanatalu K., Samoson A., Madl T., Lewandowski J.R., Characterization of protein-protein interfaces in large complexes by solid state NMR solvent paramagnetic relaxation enhancements, Journal of the American Chemical Society 139 (2017) 12165-12174
20. Stryeck S., Birner-Gruenberger R., Madl T., Integrative metabolomics as emerging tool to study autophagy regulation, Microbial Cell 4 (2017) 240-258
21. Hartlmüller C., Günther J.C., Wolter A.C., Wöhnert J., Sattler M., Madl T., RNA structure refinement using NMR solvent accessibility data, Scientific Reports 7 (2017) 5393
22. Göbl C., Focke-Tejkl M., Najafi N., Schrank E., Madl T., Kosol S., Madritsch C., Dorofeeva Y., Flicker S., Thalhamer J., Valenta R., Zangger K., Tjandra N., Flexible IgE epitope containing domains 1 of Phl p 5 cause high allergenic activity, Journal of Allergy and Clinical Immunology 40 (2017) 1187-1191
23. Bomblies R., Luitz M.O., Scanu S., Madl T., Zacharias M., Transient Helicity in Intrinsically Disordered Axin-1 Studied by NMR Spectroscopy and Molecular Dynamics Simulations, Plos One 12 (2017) e0174337
24. Lienhart W.D., Strandback E., Gudipati V., Koch K., Binter A., Uhl M.K., Rantasa D.M., Bourgeois B., Madl T., Zangger K., Gruber K., Macheroux P., Catalytic competence, structure and stability of the cancer associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1), FEBS Journal 284 (2017) 1233-1245
25. Baar M.P, Brandt R.M.C., Putavet D.A., Klein J.D.D., Derks K.W.J., Bourgeois B.R.M., Stryeck S., Rijksen Y., van Willigenburg H., Feijtel D.A., van der Pluijm I., Essers J., van Cappellen W.A., van IJcken W.F.J., Houtsmuller A.B., Pothof J., de Bruin R.W.F., Madl T., Hoeijmakers J.H.J., Campisi J., de Keizer P.L.J., Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging, Cell 169 (2017) 132-147
26. Gourinchas G., Etzl S., Göbl C., Vide U., Madl T., Winkler A., Long-range allosteric signaling in red light–regulated diguanylyl cyclases, Science Advances 3 (2017) e1602498
27. Emmanouilidis L., Schütz U., Tripsianes K., Madl T., Radke J., Rucktäschel R., Wilmanns M., Schliebs W., Erdmann R., Sattler M., Allosteric Modulation of Peroxisomal Membrane Protein Recognition by Farnesylation of the Peroxisomal Import Receptor PEX19, Nature Communications 8 (2017) 14635
28. Rodriguez Camargo D.C., Tripsianes K., Buday K., Franko A., Göbl C., Hartlmüller C., Sarkar R., Aichler M., Mettenleiter G., Schulz M., Walch A.K., Madl T., Wanker E.E., Conrad M., Hrabě de Angelis M., Reif B., The redox environment triggers conformation and aggregation of hIAPP in Type II Diabetes, Scientific Reports 7 (2017) 44041
29. Prokesch A., Graef F.A., Madl T., Moyschewitz E., Pristoynik P., Blaschitz A., Knauer M., Muenzner M., Bogner-Strauss J., Dohr G., Schulze T.J., Schupp M., Liver p53 is stabilized upon fasting and required for amino acid catabolism and gluconeogenesis, FASEB Journal 31 (2016) 732-742
2. Burgstaller S., Bischof H., Gensch T., Stryeck S., Gottschalk B., Ramadani-Muja J., Eroglu E., Rost R., Waldeck-Weiermaier M., Hay J.C., Madl T., Graier W.F., Malli R., pH-Lemon, a fluorescent protein-based self-calibrated pH reporter for acidic compartments, ACS Sensors (2019) accepted
3. Stryeck S., Gastrager M., Degoricija V., Trbušić M., Potočnjak I., Radulović B., Pregartner G., Berghold A., Madl T., Frank S., Serum Concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are Associated with Increased 3-Month Mortality in Acute Heart Failure Patients, Scientific Reports (2019) accepted
4. Schopf F.H., Huber E.M., Dodt C., Lopez A., Biebl M.M., Rutz D.A., Mühlhofer M., Madl T., Sattler M., Groll M., Buchner J., The essential co-chaperone Cns1 and the recruiter protein Hgh1 link Hsp90 to translation elongation via elongation factor 2, Molecular Cell (2019) accepted
5. Klec C, Madreiter-Sokolowski CT, Stryeck S, Sachdev V, Duta-Mare M, Gottschalk B, Depaoli MR, Rost R, Hay J, Waldeck-Weiermair M, Kratky D, Madl T, Malli R, Graier WF, Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca²⁺ Leak Directed to Mitochondria in Pancreatic Islets and β-Cells, Cellular Physiology and Biochemistry (2019) in press
6. Stadlbauer V., Horvath A., Komarova I., Schmerboeck B., Feldbacher N., Wurm S., Klymiuk I., Durdevic M., Rainer F., Blesl A., Stryeck S., Madl T., Stiegler P., Leber B., A single alcohol binge impacts on neutrophil function without changes in gut barrier function and gut microbiome composition in healthy volunteers, PLOS One (2019) accepted
7. Huber K., Hofer D.C., Trefely S.. Pelzmann H.J., Madreiter-Sokolowski C., Duta-Mare M., Schlager S., Trausinger G., Stryeck S., Graier W.F., Kolb D., Magnes C., Snyder W.N., Prokesch A., Kratky D., Madl T., Wellen K.E., Bogner-Strauss J.G., N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (2019) in press
8. Madreiter-Sokolowski C., Waldeck-Weiermair M.,Bourguignon N., Villeneuve N., Gottschalk B., Klec C., Stryeck S., Radulovic S., Parichatikanond W., Frank S., Madl T., Malli R., Graier W., Enhanced inter-compartmental Ca2+ flux modulates mitochondrial metabolism and apoptotic threshold during aging. Redox Biology (2018) in press
9. Koyani C.N., Trummer C., Shrestha N., Scheruebel S., Bourgeois B., Plastira I., Kickmaier S., Sourij H., Rainer P., Madl T., Sattler W., Pelzmann B., Malle E., von Lewinski D., Saxagliptin but not sitagliptin inhibits CaMKII and PKC via DPP9 inhibition in cardiomyocytes. Frontiers in Physiology, section Cardiac Electrophysiology (2018) in press
10. Stryeck S., Horvath A., Leber B., Stadlbauer V., Madl T., NMR spectroscopy enables simultaneous quantification of carbohydrates for diagnosis of intestinal and gastric permeability. Scientific Reports (2018) in press
11. Alkan F.A., Walter K.E., Luengo A., Madreiter-Sokolowski C.T., Stryeck S., Lau A.N., Al-Zoughbi W., Lewis C.A., Thomas C.J., Hoefler G., Graier W.F., Madl T., Vander Heiden M.G., Bogner-Strauss J.G., Cytosolic aspartate availability determines cell survival when glutamine is limiting, Cell Metabolism (2018) in press
12. Bourgeois B., Madl T., Regulation of cellular senescence via the FOXO4-p53 axis, FEBS Letters 592 (2018) 2083-2097
13. Lorenz G., Mayer C.C., Bachmann Q., Stryeck S., Braunisch M.C., Haller B., Carbajo-Lozoya J., Schmidt A., Witthauer S., Abuzahu J., Kemmner S., Angermann S., Koneru N., Wassertheurer S., Bieber R., Heemann U., Madl T., Pasch A., Schmaderer C., Acetate Free – Citrate-Acidified - Bicarbonate Dialysis Improves Serum Calcification Propensity – a Preliminary Study, Nephrology Dialysis Transplantation (2018) in press
14. Pollheimer M.J., Racedo S., Mikels-Vigdal A., Marshall D., Bowlus C., Lackner C., Madl T., Karlsen T.H., Hov J.R., Lyman S.K., Adamkewicz J., Smith V., Moreau E., Zollner G., Eide T.J., Stojakovic T., Scharnagl H., Gruber H.J., Stauber R.E., Trauner M.E., Fickert P., Senescence, Hypoxia, and Toxic Bile Promote LOXL2 Expression and E-cadherin Repression Reducing Barrier Function in Cholangiocytes, Journal of Hepatology 69 (2018) 368-377
15. Rutz D.A., Luo Q., Freiburger L., Madl T., Kaila V.R.I., Sattler M., Buchner J., A switch point in the molecular chaperone Hsp90 responding to client interaction, Nature Communications 9 (2018) 1472
16. Cristóvão J.S., Morris V.K., Cardoso I., Leal S.S., Martínez J., Botelho H.M., Göbl C., David R., Kierdorf K., Alemi M., Madl T., Fritz G., Reif B., Gomes C.M., The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation, Science Advances 4 (2018) eaaq1702
17. Hofweber M., Hutten S., Bourgeois B., Spreitzer E., Niedner-Boblenz A., Schifferer M., Ruepp M.D., Simons M., Niessing D., Madl T., Dormann D., Phase separation of FUS is suppressed by its nuclear import receptor and arginine methylation, Cell 173 (2018) 706-719
18. Bischof H., Rehberg M., Stryeck S., Artinger K., Eroglu E., Waldeck-Weiermair M., Gottschalk B., Rost R., Deak A.T., Niedrist T., Vujic N., Lindermuth H., Prassl R., Pelzmann B., Groschner K., Kratky D., Eller K., Rosenkranz A.R., Madl T., Plesnila N., Graier W.F., Malli R., Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo, Nature Communications 8 (2017) 1422
19. Öster C., Kosol S., Hartlmüller C., Lamley J.M., Iuga D., Oss A., Org M.L., Vanatalu K., Samoson A., Madl T., Lewandowski J.R., Characterization of protein-protein interfaces in large complexes by solid state NMR solvent paramagnetic relaxation enhancements, Journal of the American Chemical Society 139 (2017) 12165-12174
20. Stryeck S., Birner-Gruenberger R., Madl T., Integrative metabolomics as emerging tool to study autophagy regulation, Microbial Cell 4 (2017) 240-258
21. Hartlmüller C., Günther J.C., Wolter A.C., Wöhnert J., Sattler M., Madl T., RNA structure refinement using NMR solvent accessibility data, Scientific Reports 7 (2017) 5393
22. Göbl C., Focke-Tejkl M., Najafi N., Schrank E., Madl T., Kosol S., Madritsch C., Dorofeeva Y., Flicker S., Thalhamer J., Valenta R., Zangger K., Tjandra N., Flexible IgE epitope containing domains 1 of Phl p 5 cause high allergenic activity, Journal of Allergy and Clinical Immunology 40 (2017) 1187-1191
23. Bomblies R., Luitz M.O., Scanu S., Madl T., Zacharias M., Transient Helicity in Intrinsically Disordered Axin-1 Studied by NMR Spectroscopy and Molecular Dynamics Simulations, Plos One 12 (2017) e0174337
24. Lienhart W.D., Strandback E., Gudipati V., Koch K., Binter A., Uhl M.K., Rantasa D.M., Bourgeois B., Madl T., Zangger K., Gruber K., Macheroux P., Catalytic competence, structure and stability of the cancer associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1), FEBS Journal 284 (2017) 1233-1245
25. Baar M.P, Brandt R.M.C., Putavet D.A., Klein J.D.D., Derks K.W.J., Bourgeois B.R.M., Stryeck S., Rijksen Y., van Willigenburg H., Feijtel D.A., van der Pluijm I., Essers J., van Cappellen W.A., van IJcken W.F.J., Houtsmuller A.B., Pothof J., de Bruin R.W.F., Madl T., Hoeijmakers J.H.J., Campisi J., de Keizer P.L.J., Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging, Cell 169 (2017) 132-147
26. Gourinchas G., Etzl S., Göbl C., Vide U., Madl T., Winkler A., Long-range allosteric signaling in red light–regulated diguanylyl cyclases, Science Advances 3 (2017) e1602498
27. Emmanouilidis L., Schütz U., Tripsianes K., Madl T., Radke J., Rucktäschel R., Wilmanns M., Schliebs W., Erdmann R., Sattler M., Allosteric Modulation of Peroxisomal Membrane Protein Recognition by Farnesylation of the Peroxisomal Import Receptor PEX19, Nature Communications 8 (2017) 14635
28. Rodriguez Camargo D.C., Tripsianes K., Buday K., Franko A., Göbl C., Hartlmüller C., Sarkar R., Aichler M., Mettenleiter G., Schulz M., Walch A.K., Madl T., Wanker E.E., Conrad M., Hrabě de Angelis M., Reif B., The redox environment triggers conformation and aggregation of hIAPP in Type II Diabetes, Scientific Reports 7 (2017) 44041
29. Prokesch A., Graef F.A., Madl T., Moyschewitz E., Pristoynik P., Blaschitz A., Knauer M., Muenzner M., Bogner-Strauss J., Dohr G., Schulze T.J., Schupp M., Liver p53 is stabilized upon fasting and required for amino acid catabolism and gluconeogenesis, FASEB Journal 31 (2016) 732-742