PEAQ Isothermal Titration Calorimeter (ITC)

Vienna Biocenter Core Facilities GmbH (VBCF)

Vienna | Website

Large equipment

Short Description

Isothermal Titration Calorimetry (ITC) is a method used to analyze biomolecular interactions by measuring the heat change that occurs when two molecules interact. Heat is liberated or absorbed as a result of the redistribution of non-covalent bonds when the interacting molecules go from the free to the bound state. The resulting isotherm is fitted to a binding model to obtain the affinity (KD), stoichiometry (N) and enthalpy of interaction (ΔH). The MicroCal PEAQ-ITC isothermal titration calorimeter from Malvern Instruments has a 200 μL sample cell and provides direct measurement of the heat absorbed or evolved as a result of mixing precise amounts of reactants in liquid samples.

Contact Person

Arthur Sedivy

Research Services

-user training
-instrument booking
-biomolecular interaction measurements as full service

Methods & Expertise for Research Infrastructure

The ProTech facility can run ITC analyses on the PEAQ-ITC instrument as a full service, or provide user training so that users can book the instrument and run their own experiments. Please contact the facility for more details.

Allocation to Core Facility

Protein Technologies

Arthur Sedivy
Protein Technologies Facility
+43 1 796 2324 7231
The Vienna Biocenter Core Facilities (VBCF) is a research institute providing access to state of the art infrastructure and advanced research services on a fee-for-service basis. Additionally, VBCF core facilities are open to all forms of scientific cooperation. Information on general conditions of cooperation and usage fees is provided upon request.
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