Austrian Academy of Sciences (ÖAW)
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The Illumina NovaSeq 6000 provides ultrahigh-throughput sequencing for large sequencing projects. For genomic research it provides highest throughput and cost efficiency.
The Biomedical Sequencing Facility (BSF) is an academic core facility and center of expertise for next generation sequencing (NGS) with more than 10 years experience in NGS.
The BSF offers advice and consulting for NGS experiments, NGS service (library preparation and sequencing) and bioinformatic data analysis to researchers and clinicians in Vienna, in Austria, and internationally.
The NGS protocols offered by the BSF include genome, transcriptome, epigenome and single-cell sequencing on short- and long-read sequencing platforms.
Methods & Expertise for Research Infrastructure
The Biomedical Sequencing Facility (BSF) is Austria’s first technology platform dedicated to next generation sequencing in biomedicine and is thus expected to play a catalyzing role in the country’s development of genomic medicine.
The BSF not only operates next generation sequencing for Vienna’s medical campus (and beyond), but it also provides technological expertise and bioinformatic services for basic researchers and clinicians. Furthermore, it contributes to several flagship projects aimed at establishing proof-of-concept for genomic medicine in Austria.
• HCA|Organoid – Combining single-cell profiling with organoid technology, the HCA|Organoid project will establish an open access “Organoid Cell Atlas” within the global Human Cell Atlas (HCA, https://hca-organoid.eu) initiative.
• National COVID-19 surveillance programme: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) whole genome sequencing of individual patient samples, as well as waste water samples in collaboration with the Austrian Agency for Health and Food Safety (Österreichische Agentur für Gesundheit und Ernährungssicherheit GmbH, AGES, https://www.ages.at/en).
• Bock, C., Boutros, M., Camp, J.G. et al. The Organoid Cell Atlas. Nature Biotechnology 39, 13–17 (2021). https://doi.org/10.1038/s41587-020-00762-x
• Amman, F., Markt, R., Endler, L. et al. Viral variant-resolved wastewater surveillance of SARS-CoV-2 at national scale. Nature Biotechnology 40, 1814–1822 (2022). https://doi.org/10.1038/s41587-022-01387-y