Genomics

University of Salzburg

Salzburg | Website

Core facility (CF)

Short Description

The core facility Genomics comprises a combination of instruments for global gene expression, genome and methylome analysis as well as for the analysis of (oncogenic) signal transduction pathways (Illumina NextSeq 550; Affymetrix Gene Atlas Station; PyroMark Q24 Workstation; RotorQ qPCR cylcers)

Contact Person

Prof. Dr. Fritz Aberger

Research Services

analysis of DNA methylation
global gene expression studies
exome sequencing
genome sequencing
analysis of signal transduction mechanisms

Methods & Expertise for Research Infrastructure

The core facility Genomics serves nationale and internationale collaboration projects for the molecular, genetic, epigenetic and cell biological/biochemical and evolutionary biological analyses of biological samples, such as cancer tissues and immune cells, as well as of plant organisams.
Main applications are global gene expression studies, small and large scale analysis of epigenetic modifications such as DNA methylation in cancer cells, as well as DNA sequence analyses in the context of evolutionary biology and plant science projects.

Please contact us via science.plus@sbg.ac.at, or contact the responsible person for this section, mentioned in the contact field
Priority Program Allergy Cancer BioNano Research Centre (ACBN), University of Salzburg
Salzburg Cancer Research Institute
Paracelsus Privat Medical University (PMU), Salzburg
University Clinics Salzburg
University of Linz
University of Erlangen
University of Göttingen
German Cancer Research Institute in Heidelberg
University of Vienna
University of Ghent
Ludwig-Maximillian-Universität (LMU) Munich
Hedgehog und Interleukin-6 Signaltransduktion im Basaliom
2014-2017
Fritz Aberger
Fonds zur Förderung der wissenschaftlichen Forschung: FWF P25629
https://www.fwf.ac.at

Hedgehog-EGFR Signaltransduktion im Basaliom
2008-2011
Fritz Aberger
Fonds zur Förderung der wissenschaftlichen Forschung: FWF P20652
https://www.fwf.ac.at

Austrian Barcoding of Life (ABOL)
2017-2021
Andreas Tribsch
BMWFW

Galactinol in nematode induced syncytia
2014-2018
Holger Bohlmann (Boku Wien), Raimund Tenhaken, Maria Köhler
Fonds zur Förderung der wissenschaftlichen Forschung: FWF P 27323

Targeting E-cadherin - Functional role of E-cadherin shedding in Helicobacter pylori-associated carcinogenesis
2012-2017
Silja Wessler
Fonds zur Förderung der wissenschaftlichen Forschung: FWF P_24074
https://www.fwf.ac.at
Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium.
2017
Feng Y, Wang Y, Liu H, Liu Z, Mills C, Han Y, Hung RJ, Brhane Y, McLaughlin J, Brennan P, Bickeboeller H, Rosenberger A, Houlston RS, Caporaso NE, Teresa Landi M, Brueske I, Risch A, Ye Y, Wu X, Christiani DC, Amos CI, Wei Q.
Scientific Reports 2017 Apr 11;7(1):825
DOI: 10.1038/s41598-017-00850-0.

Helicobacter pylori Employs a Unique Basolateral Type IV Secretion Mechanism for CagA Delivery.
2017
Tegtmeyer N, Wessler S, Necchi V, Rohde M, Harrer A, Rau TT, Asche CI, Boehm M, Loessner H, Figueiredo C, Naumann M, Palmisano R, Solcia E, Ricci V, Backert S.
Cell Host & Microbe 2017 Oct 11;22(4): 552-560.e5
DOI: 10.1016/j.chom.2017.09.005.

Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells
2012
Eberl M, Klingler S, Mangelberger D, Loipetzberger A, Damhofer H, Zoidl K, Schnidar H, Hache H, Bauer HC, Solca F, Hauser-Kronberger C, Ermilov AN, Verhaegen ME, Bichakjian CK, Dlugosz AA, Nietfeld W, Sibilia M, Lehrach H, Wierling C, Aberger F.
EMBO Molecular Medicine
DOI: 10.1002/emmm.201100201

Transient alkalinization of the leaf apoplast stiffens the cell wall during onset of chloride-salinity in corn leaves.
2017
Geilfus CM, Tenhaken R, Carpentier SC
The Journal of Biological Chemistry 292, 18800-18813
http://www.jbc.org/content/292/46/18800