Advanced Imaging and Microscopy

University of Salzburg

Salzburg | Website

Core facility (CF)

Short Description

The focus of this core facility is on various light and electron microscopy methods, i.a. transmitted light-, phase contrast-, fluorescence and confocal laser scanning microscopy, scanning electron microscopy ( SEM) as well as transmission electron microscopy (TEM),analytical TEM (energy filtering, EFTEM, electron energy loss spectroscopy) and electron tomography.

All these methods require elaborate sample preparations, for example chemical and/or physical sample fixation (cryo-fixation), dehydration, embedding and sectioning/ultrathin sectioning. Examples include a cryo-sectioning microtome, a sputtering device, a high-pressure freezer (Leica Empact), a cryo-substitution device (Leica AFS), a plunge freezer (KF80, Reichert), a cryo-jet device (Balzers), a freeze-etching device (Balzers), several ultramicrotomes (Reichert Ultracut, Ultracut E, Leica UC7) a cryo-ultramicrotome, trimmers (Leica EM Trim), polymerization ovens and numerous diamond knives.
For contrast enhancement, the samples can be labelled by chemical or immunological methods or also by in situ hybridization. The samples must be applied on special slides. Electron microscopic methods can be used to study biological structures from molecular to cellular and tissue level.
In light microscopy, in particular fluorescence and confocal laser scanning microscopy (CLSM), investigation of both, fixed biological samples and living cells is possible. Therefore, in the Core Facility is also equipped with safety cabinets that enable live cell imaging, toxicological evaluations and further bioanalytical investigations.
Of particular importance are light-microscopy-guided patch clamp measurements. The measuring stations allow complete electrophysiological characterization of cells up to single channel resolution. The equipment required for this purpose, such as vibration-damped tables, manipulators, perfusion systems and computer-controlled amplifiers are available.
For the further investigation of living cells and organoids in 3D, bioreactors as well as modern microfluidic analysis systems are available, thus offering the possibility of a flow living cell microscopy. The facility also has the prerequisites for producing high-quality biochips in small quantities in very fast production cycles. In particular, there is a rapid prototyping facility with a) precision 3D printer b) polymer milling machine c) hot embossing facility d) sputtering facility e) plasma cleaner f) spin coater.

This range of methods allows a variety of applications in basic and applied research, such as aging research, allergy, tumor research, stress physiology and plant biology.

Contact Person

Ao.Univ.-Prof. Mag. Dr Gerhard Obermeyer

Research Services

confocal laser scanning microscopy
immuno fluorescence/morphometry
live cell imaging
analytical fluorescence microscopy
construction and modification of microscopy Systems
analytical TEM (electron energy loss spectroscopy)
TEM tomography
cryo-peparation methods for TEM

Methods & Expertise for Research Infrastructure

The visualization of cellular and subcellular structures provides important information about the processes within cells and tissues. Devices from this core facility can be used to examine fixed samples that provide snapshots of cellular processes at the highest resolution, as well as to observe and digitize dynamic processes in living cells.
In addition, the devices may be used for analytical purposes, e.g. using immuno reactions to localize proteins etc. in cells and tissues (immuno-TEM) or to measure subcellular elements and to calculate elemental distribution images (analytical TEM, energy loss spectroscopy). This also includes analytical fluorescence microscopy for measuring cellular signals (Ca2 +, pH) and metabolite concentrations (glucose, ATP, NADH, etc.). FRAP = fluorescence recovery after photobleaching can be used to visualize the diffusion behavior of fluorescent substances, FRET = Förster resonance energy transfer is used to measure the distance between proteins or to detect protein interactions.
The devices are used in various cell biological and molecular biology fields, which are useful in e.g. plant biology, tumor biology, immunology research, neuro biology or stress physiology. In addition, modern fluorescence microscope systems are designed, built and developed for research.


Ao.Univ.-Prof. Mag. Dr Gerhard Obermeyer
Fachbereich Biowissenschaften
0043 662 8044 7230
Please contact us via, or contact the responsible person for this section, mentioned in the contact field
Prof. Dr. Steffen Backert, University of Nürnberg-Erlangen (AG Wessler)
Takashi Ueda, University of Tokyo, Japan (AG Foissner)
Geoffrey Wasteneys, University of Vancouver, Canada (AG Foissner)
Viktor Zarsky, Czechoslovak Academy of Science, Prague (AG Foissner)
Prof. Dr. Alexander Bulychev, University of Moscow (AG Foissner)
Prof. Dr. Mary Beilby, University of New South Wales (AG Foissner)
Dr. Christian Fillafer, Technical University of Dortmund (AG Foissner)
Paracelsus Medical University (PMU) Salzburg Pulmologie SALK - Prof Studnicka (AG Minnich)
Ludwig-Maximilians University Munich Dr. Marcos V. Research cebter Childrens Hospital (AG Minnich)
University of Tübingen Dr. Hartl D. Children`s Hospital and Interdiciplinary Center for infectious Diseases
Universitätsklinikum Homburg an der Saar - Prof Hannik (AG Minnich)
Uni Salzburg Dr. Vitkov, Parodontologe (AG Minnich)
University of Salzburg, Department of Chemistry and Physics of Materials - Prof. Hüsing (AG Minnich)
3. Medicin, Karls University Prag, Prof. Kachlik / Prof. Stingl (AG Minnich)
Paracelsus Medical University (PMU), Urology, Dr. Foditsch (AG Minnich)
Paracelsus Medical University (PMU), Interventionelle Neuroradiology, Prof. Killer (AG Minnich)
Department of Forensic Medicine and Forensic Neuropsychiatry, Prof. Monticelli (AG Minnich)
Prof. Steven Devoto, H Wesleyan University of Middletown Conn, USA (AG Minnich)
Prof. Dr. Peter Hepler Amherst, University of Massachusetts (AG Lütz-Meindl)
Prof. Dr. Ulf Karsten, University of Rostock (AG Lütz-Meindl)
Prof.Dr.Gilbert Neuner, University of Innsbruck (AG Lütz-Meindl)
Die Rolle des Immunsystems in Krebserkrankungen und Allergie (Doktoratskolleg) Immunity in Cancer and Allery - ICA (docotoral programm)
Christian Huber
Fonds zur Förderung der wissenschaftlichen Forschung (FWF), W1213

Eismanagement und Gefrierdehydrierung von Pflanzenzellen (Ice management and freeze dehydration of plant cells)
Gilbert Neuner (Uni Innsbruck), Ursula Lütz-Meindl
Fonds zur Förderung der wissenschaftlichen Forschung (FWF), P 30139

Subzelluläre Lokalisierung von Schwermetallen in Mooralgen (Subcellular localization of heavy metals in bog algae)
Ursula Lütz-Meindl
Fonds zur Förderung der wissenschaftlichen Forschung (FWF), P 21035

Alterung und Zelltod in einer einzelligen Alge (Aging and cell death in a unicellular alga)
Ursula Lütz-Meindl
Fonds zur Förderung der wissenschaftlichen Forschung (FWF), P 18869

Physiologie und Lokalisierung von Pollen-Ionentransportern
Gerhard Obermeyer
Fonds zur Förderung der wissenschaftlichen Forschung (FWF), P 21298

Metabolic OsmoRegulation in Pollen (Metabolic osmoregulation in pollen)
Gerhard Obermeyer
Fonds zur Förderung der wissenschaftlichen Forschung (FWF), P29626

Sacral versus pudendal neuromodulation
Krautgartner, Stoiber
Gemeinnützige Salzburger
Koop.Partner: Prof. Janetschek, Urologie, SALK - PMU

Stoiber, Krautgartner
MSA, Clinical Research Center Salzburg G, Land Salzburg
Koop.Partner: Prof. Michael Studnicka, Pulmologie, SALK - PMU

New phylogenetic features in Oligotrichea
Agatha Sabine
Fonds zur Förderung der wissenschaftlichen Forschung (FWF), P28790

Untersuchung der Lungenvaskularisation bei COPD / Emphysemen im Mausmodell - Vascular Corrosion casting
Bernd Minnich, Katharina Erlbacher
Koop.Partner: Dr. Max Ackermann, Inst. f. Anatomie, Med.UNI Mainz, D

Untersuchung der gonadalen Vaskularisation unter Einfluss von Cannabis (THC) im Rattenmodell - Vascular Corrosion casting
Bernd Minnich, Katharina Erlbacher
Stiftungs- und Förderungsgesellschaft, Universität Salzburg - Forschungsprojekt: SF0314M
Koop.Partner: Prof. Paulmichl, Pharmakologie & Toxikologie, PMU

Untersuchung der penilen Vaskularisation bei Diabetes II im Rattenmodell - Vascular Corrosion casting
Bernd Minnich, Katharina Erlbacher
Koop.Partner: Dr. Esra Foditsch, Urologie, SALK - PMU

Untersuchung des Vasa vasorums der großen humanen Beinvene für Herz by-pass Operationen - Vascular Corrosion casting
Bernd Minnich, Markus Herbst
Koop.Partner 1: Prof. Hölzenbein, Klinik f. Vaskuläre und Endovaskuläre Chirurgie, SALK - PMU
Koop.Partner 2: Prof. Stingl, 3. Anatomie, Karls-Universität Prag, CZ

Gefäßatlas des südafrikanischen Krallenfrosches Xenopus lavis - Vascular Corrosion casting
Alois Lametschwandtner, Bernd Minnich
Fonds zur Förderung der wissenschaftlichen Forschung (FWF), P 19050-B17

Gefäßausgusspräparation BioTree Systems - Vascular Corrosion casting
Alois Lametschwandtner
Max Plank Institut für Biogeochemie Jena, Bundesforstamt Thüringer Wald, Thüringer Forst - Forschungsprojekt: BT_0610

Microvaskularization of murine organs - Vascular Corrosion casting
Alois Lametschwandtner
Max Plank Institut für Biogeochemie Jena, Bundesforstamt Thüringer Wald, Thüringer Forst - Forschungsprojekt: BT_0610

Tumorvaskularisation II - Vascular Corrosion casting
Alois Lametschwandtner
Max Plank Institut für Biogeochemie Jena, Bundesforstamt Thüringer Wald, Thüringer Forst - Forschungsprojekt: BT_0610

Funktion and localization of ion channels in chronic lymphatic leukemia cells
2013 - 2017
Coop.Partner: Prof. Dr. Greil (Laboratory for Immunological and Molecular Cancer Research, Third Medical Department with Hematology, Oncology, Hemostaseology, Infectiology, and Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria

Impact of ion channels on volume regulation in immune cells
2011 - 2019
Coop. Partner: Prof. Dr. Markus Ritter
Institute of Physiology and Pathophysiology, Paracelsus Medical University, Salzburg, Austria

Bio-monitoring of environmental pollution in the Kosovo (air and water pollution): improvement of risk assessment, public awareness and eventual remediation activities
Peter Eckl
OEAD, Impulse-Projekt

Environmental Pollution in Kosovo:potential genotoxic effects and related human health risks Europe Aid
Alija/Eckl – koordiniert von Alija/Universität Prishtina
Europe Aid

Wirkung von Beta-Carotin auf primäre Lungenzellen
Peter Eckl
Fonds zur Förderung der wissenschaftlichen Forschung (FWF), P 20096

Plus4 BIOS
Günter Lepperdinger
Land Salzburg in Kooperation mit SONY DADC Bioseinces GmbH

Günter Lepperdinger
FFG K-Project; Nr. 843536

Plasma membrane domains in internodal cells of the characean greeen algae: photosynthesis, ion currents, membrane potential and proteomics
Ilse Foissner
Fonds zur Förderung der wissenschaftlichen Forschung (FWF), P 27536

Characterization of plasma membrane domains in internodal cells of the characean green algae
Ilse Foissner
Fonds zur Förderung der wissenschaftlichen Forschung (FWF), P 22957

Apoptosis or Cell Survival: c-Abl in Helicobacter pylori-infected epithelial cells
Silja Wessler
Fonds zur Förderung der wissenschaftlichen Forschung, P24315

Targeting E-cadherin - Functional role of E-cadherin shedding in Helicobacter pylori-associated carcinogenesis
Silja Wessler
Fonds zur Förderung der wissenschaftlichen Forschung, P24074

Acetaldehyde and Ethanol Interactions on Calcium-activated Potassium (BK) Channels in Pituitary (GH3/GH4) Cells
Österreichische Akademie der Wissenschaften
Helicobacter pylori-controlled c-Abl localization promotes cell migration and limits apoptosis
Posselt G, Wiesauer M, Chichirau BE, Engler D, Krisch LM, Gadermaier G, Briza P, Schneider S, Boccellato F, Meyer TF, Hauser-Kronberger C, Neureiter D, Müller A, Wessler S
Cell Communication and Signaling 17:10

Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion
Hoy B, Löwer M, Weydig C, Carra G, Tegtmeyer N, Geppert T, Schröder P, Sewald N, Backert S, Schneider G, Wessler S.
EMBO Rep. 798-804
DOI: 10.1038/embor.2010.114. Epub 2010 Sep 3

Biomineralization of strontium and barium contributes to detoxification in the freshwater alga Micrasterias
Niedermeier, M., Gierlinger, N., Lütz-Meindl, U.
Journal of Plant Physiology

Ionic stress induces fusion of mitochondria to 3-D networks: An electron tomography study
Steiner, P., Luckner, M., Kerschbaum, H., Wanner, G., Lütz-Meindl U.
Journal of Structural Biology

Extracellular vesicles as biomarkers for the detection of a tumor marker gene in epidermolysis bullosa-associated squamous cell carcinoma
Sun, Y., Woess, K., Kienzl, M., Leb-Reichl; V.M., Feinle, A., Wimmer, M., Zauner, R., Wally, V., Luetz-Meindl, U., Mellerio, J.E., Ignacia , I., South, A.P., Bauer, J.W., Reichelt, J., Furihata, T., Guttmann-Gruber, C, Piñón Hofbauer, J.
Journal of Investigative Dermatology

The Recombinant Inhibitor of DNA Binding Id2 Forms Multimeric Structures via the Helix-Loop-Helix Domain and the Nuclear Export Signal
Roschger,C., Schubert,M., Regl, C., Andosch, A., Marquez, A., Berger, T., Huber, C.G., Lütz-Meindl, U., Cabrele, C.
International journal of molecular sciences

Hyposaline conditions affect UV susceptibility in the Arctic kelp Alaria esculenta (Phaeophyceae)
Springer, K., Lütz, C., Lütz-Meindl, U., Wendt, A., Bischof, K.
Phycologia 56(6):675-685
DOI: 10.2216/16-122.1

Carbon starvation induces lipid degradation via autophagy in the model alga Micrasterias
Schwarz, V., Andosch A., Geretschläger A., Affenzeller M., Lütz-Meindl U.
Journal of Plant Physiology

Bacterial endotoxin (LPS) binds to the surface of gold nanoparticles, interferes with protein corona formation and induces human monocyte inflammatory activation
Li Y, Shi S, Radauer-Preiml I, Andosch A, Casals E, Lütz-Meindl U, Cobaleda M, Lin Z, Jaberi-Douraki M, Italiani P, Horejs-Hoeck J, Himly M, Monteiro-Riviere N, Duschl A, Puntes V, Boraschi D

Micrasterias as a model system in plant cell biology.
Lütz-Meindl, U.
Front. Plant Sci. 7, 999;

Nanoparticle-allergen interactions mediate human allergic responses: Protein corona characterization and cellular responses.
Radauer-Preiml, I., Andosch, A., Hawranek, T., Lütz-Meindl, U., Wiederstein, M., Horejs-Hoeck, J., Himly, M., Boyles, M.S.P., Duschl, A.
Part. Fibre. Toxicol.

Enhanced depostion by electrostatic field-assistance aggravating diesel exhaust aerosol toxicity for human lung cells.
Stoehr, L.C., Madl, P., Boyles, M., Zauner, R., Wimmer, M., Wiegand, H., Andosch, A., Kasper, G., Pesch, M., Lütz-Meindl, U., Himly, M., Duschl, A.
Environ. Sci. Technol.

Structural stress responses and degradation of dictyosomes in algae analyzed by TEM and FIB-SEM tomography
Lütz-Meindl, U., Luckner, M., Andosch, A., Wanner, G.
J. Microsc.

Chitosan functionalisation of gold nanoparticles encourages particle uptake and induces cytotoxicity and pro-inflammatory conditions in phagocytic cells, as well as enhancing particle interaction with serum components.
Boyles, M.S.P., Kristl, T., Andosch, A., Zimmermann, M., Tran, N., Casals, E., Himly, M., Puntes, V., Huber, C.G., Lütz-Meindl, U., Duschl, A.
J. Nanobiotechnol.

Subcellular sequestration and impact of heavy metals on the ultrastructure and physiology of the multicellular freshwater alga Desmidium swartzii.
Andosch, A., Höftberger, M., Lütz, C., Lütz-Meindl, U.
Int. J. Mol. Sci.

Rescue of heavy metal effects on cell physiology of the algal model system Micrasterias by divalent ions.
Volland, S., Bayer,E., Baumgartner,V., Andosch, A., Lütz, C., Sima, E., Lütz-Meindl U.
J. Plant Physiol.

From the nucleus to the plasma membrane: translocation of the nuclear proteins histone H3 and lamin B1 in apoptotic microglia.
Klein, B., Lütz-Meindl U., Kerschbaum H.H. (2014).

3-D analysis of dictyosomes and multivesicular bodies in the green alga Micrasterias denticulata by FIB/SEM tomography.
Wanner, G., Schäfer T., Lütz-Meindl U.
J. Struct. Biol.

Pb-induced ultrastructural alterations and subcellular localization of Pb in two species of Lespedeza by TEM-coupled electron energy loss spectroscopy.
Zheng, L., Peer, T., Seybold, V., Lütz-Meindl, U.
Environ. Exp. Bot.

Intracellular chromium localization and cell physiological response in the unicellular alga Micrasterias.
Volland, S., Lütz, C., Michalke, B., Lütz-Meindl, U.
Aquat. Toxicol.

A freshwater green alga under cadmium stress: Ameliorating calcium effects on ultrastructure and photosynthesis in the unicellular model Micrasterias.
Andosch, A., Affenzeller, M.J., Lütz, C., Lütz-Meindl, U.
J. Plant Physiol.

Intracellular metal compartmentalization in the green algal model system Micrasterias denticulata (Streptophyta) measured by transmission electron microscopy-coupled electron energy loss spectroscopy.
Volland, S., Andosch, A., Milla, M., Stöger, B., Lütz, C., Lütz-Meindl, U.
J. Phycol.

H2O2 localization in the green alga Micrasterias after salt and osmotic stress by TEM-coupled electron energy loss spectroscopy.
Darehshouri, A., Lütz-Meindl, U.

Dissecting the subcellular membrane proteome reveals enrichment of H+ (co-)transporters and vesicle trafficking proteins in acidic zones of Chara internodal cells
Pertl-Obermeyer H, Lackner P, Schulze WX, Hoepflinger MC, Hoeftberger M, Foissner I, Obermeyer G
PLOS ONE 13:e0201480

Lost in traffic? The K+ channel of lily pollen, LilKT1, is detected at the endomembranes inside yeast cells, tobacco leaves and lily pollen
Safiarian MJ, Pertl-Obermeyer H, Lughofer P, Hude R, Bertl A, Obermeyer G
Frontiers in Plant Sciences, 6, doi:10.3389/fpls.2015.00047

Neutrophil extracellular trap (NET) formation characterises stable and exacerbated COPD and correlates with airflow limitation
Grabcanovic-Musija F, Obermayer A, Stoiber W, Krautgartner WD, Steinbacher P, Winterberg N, Bathke AC, Klappacher M, Studnicka M.
Respiratory Research

The Role of Reactive Oxygen Species (ROS) in the Formation of Extracellular Traps (ETs) in Humans.
Stoiber W, Obermayer A, Steinbacher P, Krautgartner WD.

Free DNA in cystic fibrosis airway fluids correlates with airflow obstruction.
Marcos V, Zhou-Suckow Z, Önder Yildirim A, Bohla A, Hector A, Vitkov L, Krautgartner WD, Stoiber W, Griese M, Eickelberg O, Mall MA, Hartl D.
Mediators of Inflammation

The initial inflammatory response to bioactive implants is characterized by NETosis.
Vitkov L, Krautgartner WD, Obermayer A, Stoiber W, Hannig M, Klappacher M, Hartl D.
PLoS One.

Neutrophils express distinct RNA receptors ina Non-canonical way
Berger M, Hsien C-Y, Bakele M, Marcos V, Rieber N, Kormann M, Mays L, Hofer L, Neth O, Vitkov L, Krautgartner WD, Schweinitz D, Kappler R, Hector A, Weber A and Hartl D
J Biol Chem. 287(23):19409-17

The zebrafish myotome contains tonic muscle fibers: morphological characterisation and time course of formation
Marschallinger J, Obermayer A, Steinbacher P, Stoiber W
J. Morphol. 274: 320-330
DOI: 10.1002/jmor.20095. Epub 2012 Dec 20.

Neutrophil extracellular traps are a main constituent of sputum from patients with chronic obstructive pulmonary disease
Obermayer A, Stoiber W, Krautgartner WD, Klappacher M, Kofler B, Steinbacher P, Vitkov L, Grabcanovic-Musija F, Studnicka M
PLoS One. 9(5):e97784
DOI: 10.1371/journal.pone.0097784. eCollection 2014.

Is osseointegration inflammation-triggered?
Vitkov L, Hartl D, Hannig M
Med Hypotheses

Human Neutrophils Use Different Mechanisms To Kill Aspergillus fumigatus Conidia and Hyphae: Evidence from Phagocyte Defects.
Gazendam RP, van Hamme JL, Tool AT, Hoogenboezem M, van den Berg JM, Prins JM, Vitkov L, van de Veerdonk FL, van den Berg TK, Roos D, Kuijpers TW
J Immunol. 196(3): 1272-83
DOI: 10.4049/jimmunol.1501811

On the nature of tintinnid loricae (Ciliophora: Spirotricha, Tintinnina): a histochemical, enzymatic, EDX, and high-resolution TEM study.
Agatha S. & Simon P.
Acta Protozool. 51: 1 -19 + Supplement 1 -4

Reconciling cladistic and genetic analyses in choreotrichid ciliates (Ciliophora, Spirotricha, Oligotrichea).
Agatha S. & Strüder-Kypke M.C.
J. Eukaryot. Microbiol. 59: 325 -350.

Systematics and evolution of tintinnid ciliates. In: Dolan J.R., Montagnes D.J.S., Agatha S., Coats W.D. & Stoecker D.K. (eds.): The Biology and Ecology of Tintinnid Ciliates.
Agatha S. & Strüder-Kypke M.C.
Wiley-Blackwell: 42 -84.

The tintinnid lorica. In: Dolan J.R., Montagnes D.J.S., Agatha S., Coats W.D. & Stoecker D.K. (eds.): The Biology and Ecology of Tintinnid Ciliates.
Agatha S., Laval-Peuto M. & Simon P.
Wiley-Blackwell: 17 -41.

The Biology and Ecology of Tintinnid Ciliates: i -viii + 1 -296.
Dolan J.R., Montagnes D.J.S., Agatha S., Coats W.D. & Stoecker D.K.
A John Wiley & Sons, Ltd., Publication
DOI: 10.1002/9781118358092

Redescription of Strombidium coronatum (Leegaard, 1915) Kahl, 1932 (Ciliophora, Spirotricha) based on live observation, protargol impregnation, and scanning electron microscopy.
Agatha S.
Acta Protozool. 53: 287 -294

What morphology and molecules tell us about the evolution of Oligotrichea (Protista, Ciliophora).
Agatha S. & Strüder-Kypke M.C.
Acta Protozool. 53: 77 -90 + Supplement 1 -19

Updating biodiversity studies in loricate protists: the case of the tintinnids (Alveolata, Ciliophora, Spirotrichea).
Santoferrara L.F., Bachy C., Alder V.A., Gong J., Kim Y.-O., Saccà A., Silva Neto I. D. da, Strüder-Kypke M. C., Warren A., Xu D., Yi Z., & Agatha S.
J. Eukaryot. Microbiol. 63: 651 -656 + Supplement 1 -8

Convoluted plasma membrane domains in the green alga Chara are depleted of microtubules and actin filaments.
Sommer, A., M. Hoeftberger
Plant and Cell Physiology

Molecular analysis and localization of CaARA7 a conventional RAB5 GTPase from characean algae.
Hoepflinger MC, Geretschlaeger A, Sommer A, Hoeftberger M, Hametner C, Ueda T, Foissner I
Traffic 16: 534-554

Photosynthesis-dependent formation of convoluted plasma membrane domains in Chara internodal cells is independent of chloroplast position.
Foissner, I., A. Sommer
Protoplasma 252 (4): 1085-1096

Surface pH changes suggest a role for H+/OH- channels in salinity response of Chara australis
Absolonova M, Beilby MJ, Sommer A, Hoepflinger MC, Foissner I
Protoplasma 255:851-862

Intraclass evolution and classification of the Colpodea (Ciliophora).
Foissner W., Stoeck T., Agatha S. & Dunthorn M
J. Eukaryot. Microbiol. 58: 397 -415

Is wortmannin-induced reorganization of the trans-Golgi network the key to explain charasome formation?
Foissner I, Sommer A, Hoeftberger M, Hoepflinger MC, Absolonova M
Frontiers in Plant Science 7:article 756

Pathways for external alkalinization in intact and in microwounded Chara cells are differentially sensitive to wortmannin
Bulychev AA, Foissner I
Plant Signal Behav 12:e1362518

Clathrin in Chara australis: Molecular analysis and involvement in charasome degradation and constitutive endocytosis
Hoepflinger MC, Hoeftberger M, Sommer A, Hametner C, Foissner I
Front Plant Sci 8:20

Long-Range Lateral Transport between Immobile Chloroplasts in Chara is Sensitive to Interference of Brefeldin A in Vesicle Trafficking In: Dejesus C, Trask L (eds) Chloroplasts and cytoplasm: Structure and functions.
Bulychev A, Rybina AA, Foissner I
Nova Science Publishers

Pervasion of beta-tricalcium phosphate with nanodiamond particles yields efficient and safe bone replacement material amenable for biofunctionalization and application in large-size osseous defect healing.
Stigler RG, Schimke MM, Bigus S, Steinmüller-Nethl D, Tillmann K, Lepperdinger G.
Nanomedicine. 250-257
DOI: 10.1016/j.nano.2018.08.015. Epub 2018 Sep 26.

Hard Tissue Augmentation of Aged Bone by Means of a Tin-Free PLLA-PCL Co-Polymer Exhibiting in vivo Anergy and Long-Term Structural Stability.
Schimke MM, Paul S, Tillmann K, Lepperdinger G, Stigler RG.
Gerontology. 65(2):174-185
DOI: 10.1159/000494798. Epub 2019 Jan 24. PMID: 30677770

Long-lived murine osteocytes are embodied by craniofacial skeleton in young and old animals whereas they decrease in number in postcranial skeletons at older ages.
Stigler RG, Becker K, Kloss FR, Gassner R, Lepperdinger G.
Gerodontology. 35(4):391-397. doi: 10.1111/ger.12362. Epub 2018 Jul 27.
DOI: 10.1111/ger.12362. Epub 2018 Jul 27. PMDI: 30052290

Intrinsically 32P-labeled diamond nanoparticles for in vivo imaging and quantification of their biodistribution in chicken embryos Adv. Funct. Mater.2018, 28, 1802873, DOI: 10.1002/adfm.201802873
P. Happel, T. Waag, M. M. Schimke, S. Schweeberg, A. Muzha, K. Fortak, D. Heesch, L. Klask, M. Pilscheur, F. Hoppe, T. Lenders, J. Meijer, G. Lepperdinger, A. Krueger
Adv. Funct. Mater.2018, 28, 1802873
DOI: 10.1002/adfm.201802873

Biofunctionalization of scaffold material with nano-scaled diamond particles physisorbed with angiogenic factors enhances vessel growth after implantation.
Schimke MM, Stigler R, Wu X, Waag T, Buschmann P, Kern J, Untergasser G, Rasse M, Steinmüller-Nethl D, Krueger A, Lepperdinger G.
DOI: 10.1016/j.nano.2015.11.004. Epub 2015 Dec 3. PMID: 26654993

Lab-on-a-chip technologies for stem cell analysis.
Ertl P, Sticker D, Charwat V, Kasper C, Lepperdinger G.
Trends Biotechnol. 32(5): 245-53
DOI: 10.1016/j.tibtech.2014.03.004. Epub 2014 Apr 9. Review. PMID: 24726257

Age-related changes in the composition of the cornified envelope in human skin.
Rinnerthaler M.,Duschl J.,Steinbacher P., Salzmann M., Bischof J., Schuller M., Wimmer H.,
Peer T., Bauer J.W., Richter K.
Exp. Dermatol. 22, 329 – 335

Skin aging , gene expression and calcium.
Rinnerthaler M., Streubel M.K., Bischof J., Richter K.
Exp. Gerontol. 68, 59 – 65

Oxidative Stress in Aging Human Skin.
Rinnerthaler M., Bischof J., Streubel M.K., Trost A., Richter K.
Biomolecules 5, 545 – 589

Changes in the composition of the cornified envelope during skin aging: a calcium centric
Streubel M.K., Rinnerthaler M., Bischof J., Richter K.
In book: Textbook of aging skin, Editors: Miranda A. Farage Ph.D., Kenneth W. Miller Ph.D., Howard I. Maibach M.D.
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Glycine modulates membrane potential, cell volume, and phagocytosis in murine microglia
Komm B, Beyreis M, Kittl M, Jakab M, Ritter M, Kerschbaum HH.
Amino Acids 46(8): 1907-17

Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 Blockade
Grössinger EM, Weiss L, Zierler S, Rebhandl S, Krenn PW, Hinterseer E, Schmölzer J, Asslaber D, Hainzl S, Neureiter D, Egle A, Piñón-Hofbauer J, Hartmann TN, Greil R, Kerschbaum HH.
Leukemia (4): 954-8

Chloride channel blockers suppress formation of engulfment pseudopodia in microglial cells
Harl B, Schmölzer J, Jakab M, Ritter M, Kerschbaum HH.
Cell Physiol Biochem. 31(2-3): 319-37

Perturbation of intracellular K+ homeostasis with valinomycin promotes cell death by mitochondrial swelling and autophagic processes
Klein B, Wörndl K, Lütz-Meindl U, Kerschbaum HH.
Apoptosis 16(11): 1101-17
DOI: 10.1007/s10495-011-0642-9

cAMP-dependent chloride conductance evokes ammonia-induced blebbing in the microglial cell line, BV-2
Svoboda N, Pruetting S, Grissmer S, Kerschbaum HH.
Cell Physiol Biochem. 24(1-2): 53-64

Chloride influx provokes lamellipodium formation in microglial cells
Susanna Zierler, Eva Frei, Stephan Grissmer, and Hubert H Kerschbaum
Cell Physiol Biochem. 21(1-3): 55-62

Progesterone-associated increase in ERP amplitude correlates with an improvement in performance in a spatial attention paradigm
Brötzner CP, Klimesch W, Kerschbaum HH
Brain Res. 1595: 74-83

Associations of endogenous 17-β-estradiol with theta amplitude and performance in semantic categorization in young women
Brötzner CP, Klimesch W, Kerschbaum HH.
Neuroscience. 2846: 85-92

Differential effects of androgenic and anti-androgenic progestins on fusiform and frontal gray matter volume and face recognition Performance
Pletzer B, Kronbichler M, Kerschbaum H
Brain Res. 1596: 108-15

Acetaldehyde-ethanol interactions on calcium-activated potassium (BK) channels in pituitary tumor (GH3) cells
Handlechner, A.G., Hermann, A., Fuchs, R., Weiger, T.M.
Front Behav Neurosci.;7:58
DOI: 10.3389/fnbeh.2013.00058

Phosphorylation of BK Channels Modulates the Sensitivity to Hydrogen Sulfide (H2S)
Sitdikova, GF., Fuchs, R., Kainz, V., Weiger, T.M., Hermann A.
Front Physiol.;5:431
DOI: 10.3389/fphys.2014.00431.

Atmospheric pollution in Kosovo is associated with increased DNA damage in the human population
Avdulla J. Alija, Fisnik Asllani, Ismet D. Bajraktari, Andrew Richard Collins, Shemsedin Dreshaj, Nikolaus Bresgen, Peter M. Eckl
Biomonitoring, 2: De Gruyter, 35-41

An Ecological Disaster Zone with Impact on Human Health. Encyclopedia of Environmental Health
Erdinger L., Hollert H., Eckl P.
Aral Sea: 1. Burlington: Elsevier, 136–144

Carotenoids and mutagenesis. In: Carotenoids and Vitamin A in translational medicine
Eckl P.M., Alija A., Bresgen N., Bojaxhi E, Vogl C., Martano G., Stutz H., Knasmüller S., Ferk F., Siems W.G., Langhans C.D., Sommerburg O.
Boca Raton London New York: CRC Press, 151-169

N-nitrosodiethylamine genotoxicity evaluation: a cytochrome P450 induction study in rat hepatocytes
C.A.F. Aiub, G. Gadermaier, I.O. Silva I. Felzenszwalb, L.F.R. Pinto, F. Ferreira, P. Eckl
Genetics and Molecular Research, 10, 2340-2348

Iron mediated oxidative stress plays an essential role in ferritin induced cell death
Bresgen N., Jaksch H., Lacher H., Ohlenschläger I., Uchida K., Eckl P.M.
Free Radical Biology and Medicine, 48, 1347-1357

Antimutagenic effects of ethanolic extracts from selected Palestinian medicinal plants
Khader M., Bresgen N., Eckl P.M .
Journal of ethnopharmacology, 127(2), 319-324

In vitro toxicological properties of thymoquinone
Mohannad Khader, Nikolaus Bresgen, Peter M. Eckl
Food and Chemical Toxicology, 47: Elsevier, 129-133

Evaluation of the toxicological properties of ground- and surface-water samples from the Aral Sea Basin
Bosch K., Erdinger L., Ingel F., Khussainova S., Utegenova E., Bresgen N., Eckl P.M.
Science of the Total Environment, 374(1), 43-50

β-Carotene breakdown products enhance genotoxic effects of oxidative stress in primary hepatocytes
Alija, A.J., Bresgen N., Sommerburg O., Langhans C.-D., Siems W. and Eckl, P.M.
Carcinogenesis, 27(6): Oxford University Press, 1128-1133

Acetaldehyde-ethanol interactions on calcium-activated potassium (BK) channels in pituitary tumor (GH3) cells
Handlechner, A.G., Hermann, A., Fuchs, R., Weiger, T.M.
Front Behav Neurosci.;7:58
DOI: 10.3389/fnbeh.2013.00058

Phosphorylation of BK Channels Modulates the Sensitivity to Hydrogen Sulfide (H2S)
Sitdikova, GF., Fuchs, R., Kainz, V., Weiger, T.M., Hermann A.
Front Physiol.;5:431
DOI: 10.3389/fphys.2014.00431.

Homocysteine augments BK channel activity and decreases exocytosis of secretory granules in rat GH3 cells
Gaifullina AS, Yakovlev AV, Mustafina AN, Weiger TM, Hermann A, Sitdikova GF.
FEBS Lett. 2016 Oct;590(19):3375-3384
DOI: 10.1002/1873-3468.12381